AURA Biomedical

AURA Biomedical Engine is an AI-powered biomedical research and drug discovery platform for scientists, researchers, students, and biotechnology professionals. AURA synthesizes data across 8+ global biomedical databases to deliver target intelligence, 3D structural visualization, clinical safety analytics, and pharmacological profiling. KEY FEATURES & CAPABILITIES • Target Score & Intelligence Brief: Evaluates target feasibility with an automated 0–100 score synthesizing bioactivity, GTEx tissue expression specificity, FDA safety logs, and clinical trial progression likelihood. • ADMET & Lipinski Drug-Likeness Spider Chart: Analyzes absorption, distribution, metabolism, excretion, and toxicity profiles. Compares molecular weight, LogP lipophilicity, H-bond donors/acceptors, and polar surface area against Lipinski boundaries. • 3D Protein Conformer Visualizer & Dual Overlay: Renders interactive 3D cartoon representations powered by 3Dmol.js. Overlays predicted AlphaFold structures against RCSB PDB crystal conformers to analyze structural alignment. • FDA Safety & Adverse Event Analytics: Accesses OpenFDA safety logs, patient reaction statistics, hospitalization ratios, fatal outcome frequencies, and demographic gender breakdowns. Exports reaction data to CSV. • Clinical Trials Intelligence & Outcome Tracking: Tracks study progress, phase II/III distributions, sponsor portfolios, and historical success rates via the ClinicalTrials.gov API. • Sequence Homology & BLAST Explorer: Searches amino acid sequences or UniProt accession IDs to scan sequence alignment identity and identify homologous protein targets. • Genomics & Tissue Expression Profiling: Displays Ensembl genomic loci, splice transcript isoforms, gnomAD constraint scores (pLI / LOEUF), and GTEx median tissue expression levels across human tissues. • Comparative Matrix & Heatmap Drawer: Compares multiple target leads side-by-side in a color-coded metric heatmap. LIVE DATABASE INTEGRATIONS • UniProtKB & RCSB PDB (Protein Sequences & 3D Structures) • AlphaFold EBI Database (3D Structure Predictions) • OpenFDA (Drug Safety & Adverse Event Reports) • ClinicalTrials.gov (Global Clinical Trial Registries) • ChEMBL & PubChem (Bioactivity & Chemical Descriptors) • GTEx Portal & Ensembl (Expression & Genomic Structures) • Europe PMC (Scientific Literature & Publications) PRIVACY & COMPLIANCE AURA does not track users or contain advertising networks. Searches and screening library items can be stored with cloud persistence. Disclaimer: AURA Biomedical Engine is designed exclusively for scientific research, educational, and reference purposes. It is not intended for medical diagnosis, clinical decision-making, or direct patient care.